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. 2019 Feb 15;146(4):dev174748. doi: 10.1242/dev.174748

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Bmp2 expression during semicircular canal formation. (A) A mid-section through the vertical canal pouch at E11.75. Bmp2 is broadly expressed in the fusion plate (arrowheads) and the rim region of the canal pouch (bracket). (B) Adjacent section to A showing Lmo4 is exclusively expressed in the rim domain (bracket). (C) At E15.5, Bmp2 is expressed in the entire canal epithelium. (D) A high-magnification view of the rectangle in C. (E-G) Adjacent sections of the anterior semicircular canal at E17.5 probed for Bmp2 (E), Dlx5 (F) and Ntn1 (G). Bmp2 is restricted to the outer rim of the canal (E), overlapping with the Dlx5 domain (F). In contrast, Ntn1 shows a complementary expression pattern with Bmp2 (E) and Dlx5 (G). Arrows are pointing away from the outer rim of the canal. ed, endolymphatic duct. Orientations: A, anterior; L, lateral. Orientation in A also applies to B-G. Scale bars: 100 μm in A for A,B; 100 μm in C; 100 μm in D for D-G.