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. 2019 Feb 15;146(4):dev168146. doi: 10.1242/dev.168146

Fig. 1.

Fig. 1.

Liver-specific Cnot3 suppression results in decreased body mass and abnormal liver histology. (A) Immunoblot of tissue lysates from 4-week-old (4 w) control (Ctrl) and Cnot3LKO (KO) mice. (B) Immunoblot of anti-Cnot3 immunoprecipitates and lysates from 4 w Ctrl and KO livers. (C) Immunoblot of liver lysates from Ctrl and KO mice. (D,E) Appearances of whole body (D) and liver (E) of control and Cnot3LKO mice. (F,G) Body (F) and liver (G) weights of control and Cnot3LKO male mice (1-4 w, n=7; 8 w, n=5). (H) Hematoxylin and Eosin-stained livers from control and Cnot3LKO mice. (I) Oil Red-O stained livers from control and Cnot3LKO mice. (J) Appearances of spleen (left panels) and thymus (right panels) from control and Cnot3LKO mice. (K) Spleen and thymus weights of control and Cnot3LKO male mice (4 w, n=7; 8 w, n=5). Scale bars: 10 mm in D; 5 mm in E,J; 50 μm in H,I. Data are mean±s.e.m. *P<0.05, **P<0.01, ***P<0.001.