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. 2019 Feb 15;146(4):dev168146. doi: 10.1242/dev.168146

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Gene expression levels and GO analysis show upregulation of immunoresponses and cell-cycle events, and downregulation of liver function in Cnot3^−/− livers. (A) Scatter plot of mRNA expression in livers from 4-week-old (4 w) control and Cnot3LKO mice (n=2). Eight transcripts showing the largest differences are indicated. (B) Bar plot of the number of probe sets upregulated (black bars) or downregulated (white bars) with changes in Cnot3^−/− livers relative to controls. (C,D) GO analysis of mRNAs upregulated >2-fold (C) or downregulated (D) >2-fold in Cnot3^−/− livers compared with controls. Bar charts of the top 12 GO terms ranked by P value are shown. Gene lists included in each GO term are summarized in Table S2. (E,F) Venn diagram illustrating the overlap of genes upregulated >2-fold (E) or downregulated (F) >2.0-fold in Cnot3^−/− livers between 1 w (circled red) and 4 w (circled blue).