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. 2019 Jan 22;8(2):bio036657. doi: 10.1242/bio.036657

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Effects of ionizing radiation on the AKT survival pathway or MAPK pathway in Aβ42-expressing flies. (A) The levels of phosphorylated (p)-AKT, p-GSK-3β and p-p70S6K in the heads of Aβ42-expressing flies (elav>Aβ42) after exposure to γ-irradiation (0.05 Gy or 4 Gy), compared to elav-GAL4 control flies, determined by western blot. AKT, GSK-3β and actin were used as controls, respectively. (B) Graph shows the relative p-AKT levels in the heads of each group compared to elav-GAL4 control flies (n=4). (C) The levels of p-p38, p-JNK and p-ERK in the heads of indicated groups by western blot. Actin, JNK and ERK were used as controls, respectively. (D) Graph shows the relative levels of p-p38 in the heads of each group compared to elav-GAL4 control flies (n=5). Data are expressed as mean±s.e.m. *P<0.05, **P<0.01, ***P<0.001. -, untreated control.