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. 2019 Jan 23;8(2):bio039800. doi: 10.1242/bio.039800

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — FOXF1 deletion alters expression of pro-fibrotic genes in hepatic myofibroblasts. (A) qRT-PCR analysis of primary hepatic stromal cells submitted for RNA sequencing shows that Foxf1 mRNA is not detected (n.d.) in αSMACreER;Foxf1^−/− livers. Samples were pooled for further analysis. (B) Heat map shows differentially expressed genes in stromal cells from Foxf1^fl/fl and αSMACreER;Foxf1^−/− livers after chronic CCl₄-induced hepatic injury as identified by RNA-seq analysis. (C) Biological processes influenced by the deletion of Foxf1 were identified using ToppFunn. P-values and number of genes are listed for each classification. (D) 905 overlapping genes were identified between ChIP-seq (GEO accession GSE100149) and RNA-seq (GEO accession GSE123726) data, of which 74 were ECM-related genes. (E) Table shows 20 ECM-related genes identified by ChIP-seq and RNA-seq (FOXF1 binding was analyzed within 2 KB from transcriptional start site).