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. 2019 Feb 7;12(2):dmm036186. doi: 10.1242/dmm.036186

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — AAV-mediated hepatic IRA expression induces an improvement in glucose uptake in liver and muscle. (A) Quantification of in vivo hepatic glucose uptake represented as standard uptake values (SUVs). (B) Quantification of in vivo glucose uptake by gastrocnemius represented as SUVs. Animals analyzed by PET belonged to HFD (n=9), HFD-GFP (n=6), HFD-IRA (n=8) and HFD-IRB (n=7) groups. (C) Graph showing body weight gain in STD (n=5), HFD (n=9), HFD-IRA (n=8) and HFD-IRB (n=7) mice from weaning to 28 weeks of age. (D) Quantification of NMR images after AAV injection of mice in HFD (n=8), HFD-GFP (n=9), HFD-IRA (n=9) and HFD-IRB (n=9) groups. Results are expressed as mean±s.e.m. Statistical significance was assessed by two-tailed unpaired Student's t-test [versus HFD mice (^$$P<0.01), versus HFD-GFP mice (^±P<0.05 and ^±±P<0.01) and versus HFD-IRB mice (^†††P<0.001)].