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. 2019 Feb 7;12(2):dmm036186. doi: 10.1242/dmm.036186

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Hepatic IRA expression alleviates intrahepatic lipid accumulation. (A) Representative images of Oil Red O staining to study hepatic-specific lipid accumulation. Image magnification: ×20. (B) Quantification of hepatic-specific lipid content in STD (n=5), HFD (n=6), HFD-GFP (n=5), HFD-IRA (n=6) and HFD-IRB (n=6) mice. (C) Circulating cholesterol levels (mg/dl) in STD (n=5), HFD (n=8), HFD-GFP (n=6), HFD-IRA (n=8) and HFD-IRB (n=6) mice. (D) Circulating triglyceride levels (mg/dl) in STD (n=5), HFD (n=8), HFD-GFP (n=6), HFD-IRA (n=8) and HFD-IRB (n=7) mice. Results are expressed as mean± s.e.m. Statistical significance was assessed by two-tailed unpaired Student's t-test [versus STD mice (*P<0.05 and **P<0.01), versus HFD mice (^$$P<0.01), versus HFD-GFP mice (^±P<0.05) and versus HFD-IRB mice (^††P<0.01)].