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. 2019 Feb 12;12(2):dmm036863. doi: 10.1242/dmm.036863

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Histological assessment of pathological alterations in mice expressing the Kras^Lox-G12D allele. (A) Representative H&E-stained lung sections of Kras^+/LSL-G12D mice infected with Ad5-CMV-Cre expression and analysed 20 weeks p.i. The different pathologies detected in the far left image are magnified in images i-iii, showing representative examples of alveolar hyperplasia (i), papillary adenoma (ii) and papillary endobronchial lesions (iii). (B) Quantitative assessment of each pathology detected in H&E-stained sections of lung tissue collected from Kras^+/LSL-G12D mice infected with either Ad5-CMV-Cre (n 4) or Ad5-mSPC-Cre (n=3) at endpoint (20 and 40 weeks, respectively).