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. 2019 Feb 25;10:287. doi: 10.3389/fimmu.2019.00287

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Copyright © 2019 Guo, Liu, Yin, Kan, Gong, Li, Cao, Wang, Xu, Ma, Fu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of licochalcone A on pathological injury of mammary gland in LPS-induced mice mastitis. Mammary gland tissues from each experimental group (n = 10) were obtained at 24 h after LPS administration, sectioned and stained with H&E (original magnification 100 ×). Mammary gland tissues of (A) control group, (B) LPS group, (C) LPS + licochalcone A (5 mg/kg) group, (D) LPS + licochalcone A (10 mg/kg) group, and (E) LPS + licochalcone A (15 mg/kg) group. (F) Mean injury scores of mammary glands were determined according to a previously described three-point scale. Values are presented as means ± SD (**p < 0.01 and **** p < 0.0001 vs. LPS group).