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. Author manuscript; available in PMC: 2019 Nov 8.
Published in final edited form as: J Med Chem. 2018 Oct 19;61(21):9647–9665. doi: 10.1021/acs.jmedchem.8b01126

Scheme 1.

Scheme 1.

General synthetic prcedures for sulfonamides 12, 13, 16, 29. Reagents and conditions: (a) chlorosulfonic acid, 100 °C, 71%; (b) DIPEA, amine, THF then NaH, 2-(trimethylsilyl)ethanol; (c) CsF, DMF, 60 °C, 84% or TBAF, THF, 34%; (d) NCS, CHCl3, 600C, 24%.