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. Author manuscript; available in PMC: 2019 Nov 8.
Published in final edited form as: J Med Chem. 2018 Oct 19;61(21):9647–9665. doi: 10.1021/acs.jmedchem.8b01126

Scheme 3.

Scheme 3.

General synthetic procedures for 19, 22, and 26. Reagents and conditions: (a) NCS, CHCl3, 78%; (b) K2CO3, BnBr, ACN, 89%; (c) 2-trimethylsilylethanethiol (example 19) or R1SH (examples 22 and 26), Xantphos, Cs2CO3, Pd2(dba)3, dioxane, 100 °C, 93% example 19; 81% example 22, 93% example 26; (d) for example 19, 4-fluoroiodobenzene, TBAF, Xantphos, Cs2CO3, Pd2(dba)3, dioxane, 90 °C, 93%; (e) mCPBA, DCM; (f) 6M aqueous HCl, 100 °C.