Fig. 1.

Phenotype of wild-type (WT) and Ppara-null (KO) mice dosed with gemfibrozil for 14 days. a Body weight of WT mice treated with three dosages of gemfibrozil. b Calculated gemfibrozil consumption by WT and KO mice over course of study. c Serum gemfibrozil concentration monitored on days 0, 7, and 14 in WT and KO mice dosed with gemfibrozil diet. d Liver/body weight ratios of WT and KO mice dosed with gemfibrozil. The data are expressed as mean ± SD (n = 5). The *, **, and *** indicatep < 0.05, p < 0.01, and p < 0.001, respectively, compared with control or between indicated groups