Fig. 8.

Differentially regulated expression of genes involved in bile acid (BA) metabolism in liver tissues of wild-type (WT) and Ppara-null (KO) mice dosed with gemfibrozil diet for 14 days. a Relative mRNA levels from genes associated with de novo synthesis and uptake of BA by hepatocytes. b Relative mRNA levels from genes associated with basolateral and canalicular excretion of BA by hepatocytes. The data were expressed as mean ± SD (n = 5). The *, **, and *** indicate p < 0.05, p < 0.01, and p < 0.001, respectively, compared with control or between indicated groups