Table 2.
Incidence rates of osteonecrosis of the jaw (ONJ) and other characteristics in the enrolled study participants at the end of the 13-year follow-up period
| Total | Sjögren’s syndrome With |
Without | P value | |
| N (%) | N (%) | N (%) | ||
| Total | 66 990 | 13 398 (20.00) | 53 592 (80.00) | |
| ONJ | 28 (0.04) | 11 (0.08) | 17 (0.03) | 0.017* |
| Gender | 0.999 | |||
| Male | 12 530 (18.70) | 2506 (18.7) | 10 024 (18.7) | |
| Female | 54 460 (81.30) | 10 892 (81.30) | 43 568 (81.30) | |
| Age (years) | 59.63±17.54 | 57.40±16.88 | 60.19±17.66 | <0.001* |
| Malignancy | 10 825 (16.16) | 1616 (12.06) | 9209 (17.18) | <0.001* |
| DM | 9794 (14.62) | 1292 (9.64) | 8502 (15.86) | <0.001* |
| Hypertension | 10 984 (16.4) | 2171 (16.20) | 8813 (16.44) | 0.506 |
| CKD | 2115 (3.16) | 218 (1.63) | 1897 (3.54) | <0.001* |
| Osteoporosis | 1268 (1.89) | 425 (3.17) | 843 (1.57) | <0.001* |
| Bisphosphonates | 6471 (9.66) | 1454 (10.85) | 5017 (9.36) | <0.001* |
| Steroids | 2775 (4.14) | 2633 (19.65) | 142 (0.26) | <0.001* |
| Radiotherapy | 46 (0.07) | 4 (0.03) | 42 (0.08) | 0.063 |
| Chemotherapy | 526 (0.79) | 152 (1.06) | 384 (0.72) | <0.001* |
P value (categorical variable: χ 2/Fisher exact test; continuous variables: t test).
CKD, chronic kidney disease; DM, diabetes mellitus.