Table 3.

Factors associated with osteonecrosis of the jaw according to the Cox regression model

Variables	Crude HR	95% CI	P value	Adjusted HR	95% CI	P value
Sjögren’s syndrome	9.047	3.937 to 20.787	<0.001	7.635	3.126 to 18.649	<0.001*
Gender (male)	2.470	1.140 to 5.352	0.022	2.533	1.115 to 5.556	0.020*
Age (≧60 years vs 20–29 years)	1.035	0.138 to 7.770	0.974	1.024	0.131 to 8.014	0.982
Malignancy	1.838	0.781 to 4.326	0.163	1.593	0.659 to 3.848	0.301
DM	0.817	0.310 to 2.155	0.683	1.147	0.417 to 3.150	0.791
Hypertension	0.624	0.236 to 1.651	0.343	0.643	0.233 to 1.775	0.395
Osteoporosis	3.733	0.886 to 15.731	0.073	2.939	0.679 to 12.722	0.149
Bisphosphonates	2.538	1.029 to 6.260	0.043	2.488	1.005 to 6.156	0.045*
Steroids	3.903	0.900 to 16.928	0.069	1.016	0.218 to 4.742	0.984
Radiotherapy	1.355	0.973 to 5.034	0.792	1.230	0.783 to 4.526	0.637
Chemotherapy	1.421	0.875 to 4.010	0.675	1.211	0.685 to 3.097	0.589

P values <0.05 were considered statistically significant HR.

Adjusted HR, adjusted variables listed in the table; DM, diabetes mellitus.