Fig.3.

Effects of trazodone use on MMSE are dependent on sleep symptom severity at baseline and on their longitudinal improvement. Post-hoc analyses of trazodone effects on longitudinal MMSE performance in 25 trazodone users and 25 trazodone non-users when accounting for (A) presence or (B) absence of sleep complaints at baseline evaluation, and (C) changes (improvement, worsening or stability) in sleep complaints between baseline and final evaluations. MMSE inter-evaluation interval was 4.12 years. Error bars indicate standard error of the mean. See text for details.