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. 2019 Mar 4;14(3):e0213304. doi: 10.1371/journal.pone.0213304

Table 2. Characteristics of 33 confirmed TB patients, stratified by QFT-Plus results.

Characteristics Total QFT-Plus (-) QFT-Plus (+) p-value
(n = 33) (n = 15) (n = 18)
Age (years), median (IQR) 9.8 (2.3, 13.4) 6.5 (2.2, 10.4) 11.5 (2.3, 13.8) 0.08
Age (years)       0.20
    0–5 12 (36.4) 7 (46.7) 5 (27.8)  
    6–10 6 (18.2) 4 (26.7) 2 (11.1)  
    11–15 13 (39.4) 4 (26.7) 9 (50.0)  
    16–17 2 (6.1) 0 (0.0) 2 (11.1)  
Male gender 17 (51.5) 8 (53.3) 9 (50.0) 0.85
BMI z-score ≤-2 13 (39.4) 6 (40.0) 7 (38.9) 0.95
History of TB 2 (6.1) 1 (6.7) 1 (5.6) 0.89
At least one clinical sign or symptom consistent with TB 24 (72.7) 9 (60.0) 15 (83.3) 0.13
Chest radiograph consistent with TB       0.01
    No 8 (24.2) 5 (33.3) 3 (16.7)  
    Yes 18 (54.5) 4 (26.7) 14 (77.8)  
    Not done 7 (21.2) 6 (40.0) 1 (5.6)  
Sputum AFB Smear       0.09
    Negative 3 (9.1) 0 (0.0) 3 (16.7)  
    Positive 5 (15.2) 1 (6.7) 4 (22.2)  
    Unknown/Not done 25 (75.8) 14 (93.3) 11 (61.1)  
Sputum culture       <0.001
    Negative 10 (30.3) 9 (60.0) 1 (5.6)  
    Positive 18 (54.5) 3 (20.0) 15 (83.3)  
    Unknown/Not done 5 (15.2) 3 (20.0) 2 (11.1)  
Biopsy results (both pulmonary and EPTB samples)       <0.001
    Negative 3 (9.1) 1 (6.7) 2 (11.1)  
    Positive 15 (45.5) 13 (86.7) 2 (11.1)  
    Unknown/Not done 15 (45.5) 1 (6.7) 14 (77.8)  
GenXpert       0.004
    Negative 19 (57.6) 11 (73.3) 8 (44.4)  
    Positive 9 (27.3) 0 (0.0) 9 (50.0)  
    Unknown/Not done 5 (15.2) 4 (26.7) 1 (5.6)  
TB site category       <0.001
    Exclusive EPTB 7 (21.2) 6 (40.0) 1 (5.6)  
    Concomitant PTB and EPTB 7 (21.2) 6 (40.0) 1 (5.6)  
    Exclusive PTB 19 (57.6) 3 (20.0) 16 (88.9)  
Specific TB site (patient may have multiple lesion sites)        
    Pulmonary 26 (78.8) 9 (60.0) 17 (94.4) 0.02
    Lymph nodes 9 (27.3) 7 (46.7) 2 (11.1) 0.02
    Bone 4 (12.1) 4 (26.7) 0 (0.0) 0.02
    Pleural 1 (3.0) 1 (6.7) 0 (0.0) 0.27

Values are in frequency and % unless otherwise indicated; IQR, interquartile range; TB, tuberculosis; BCG, Bacille Calmette-Guerin; BMI, body mass index; AFB, Acid- Fast Bacilli; PTB, pulmonary TB; EPTB, extra-pulmonary TB