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. Author manuscript; available in PMC: 2019 Mar 4.
Published in final edited form as: Circ Res. 2018 Feb 2;122(3):489–505. doi: 10.1161/CIRCRESAHA.117.311147

Figure 4. mTORC1 modulation of autophagy and lysosomal function.

Figure 4

Schema representing the molecular mechanisms through which mTORC1 inhibits autophagy and lysosomal function. Legend: AMBRA1, (activating molecule in Beclin1-regulated autophagy; ATG, autophagy-related gene; FIP200, focal adhesion kinase family interacting protein of 200 kD; LC3, Light chain 3; ULK1/2, unc-51-like kinase 1/2; TFEB, transcription factor EB.

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