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Schema representing the molecular mechanisms through which mTORC1 inhibits autophagy and lysosomal function. Legend: AMBRA1, (activating molecule in Beclin1-regulated autophagy; ATG, autophagy-related gene; FIP200, focal adhesion kinase family interacting protein of 200 kD; LC3, Light chain 3; ULK1/2, unc-51-like kinase 1/2; TFEB, transcription factor EB.
