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. Author manuscript; available in PMC: 2019 Mar 4.
Published in final edited form as: Toxicol Appl Pharmacol. 2017 May 18;329:1–8. doi: 10.1016/j.taap.2017.05.015

Fig. 2. NA and NA-GSH levels in mouse lung and liver after a single 4-hour nose-only inhalation exposure to different doses of NA.

Fig. 2.

Two-month old wild-type (WT) and liver-Cpr-null (LCN) male mice were exposed to 5 or 10 ppm of naphthalene (NA) for 4 h. Lung (A, C) and liver (B, D) were collected 0, 2, 4 and 20 hours after termination of NA exposure. NA (A, B) and naphthalene-glutathione conjugate (NA-GSH) (C, D) were detected in tissue homogenates. Data represent means ± SD (n=3–5). ****, p<0.0001; *, p<0.05; vs WT, of corresponding dose/time point; &&&&, p<0.0001; &&&, p<0.001; vs 5 ppm, of corresponding genotype/time point (two-way ANOVA followed by Bonferroni’s test for multiple comparisons).