Table 2.

Pharmacokinetic parameters of NA and NA-GSH in the plasma of WT and LCN mice after NA inhalation exposure at 10 ppm

Values were derived from data presented in Figure 1.

Analyte, strain	AUC0–6h, μg/ml/min	t1/2, min	CL/F, ml/min	Cmax, ng/ml
NA
WT	13.2±1.8	111±7	15.8±1.3	76.5±2.6
LCN	28.6 ±4.5*	158±16*	7.9±1.5*	159±17*
NA-GSH
WT	3.0±0.2	N/A	N/A	153±49
LCN	33.6±10.5*	N/A	N/A	445±84*

^*p<0.01 (Student’s t-test), compared to corresponding WT mice

N/A, not applicable