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. Author manuscript; available in PMC: 2019 May 3.
Published in final edited form as: Cell Stem Cell. 2018 Apr 19;22(5):698–712.e9. doi: 10.1016/j.stem.2018.03.009

Figure 3. Characterization of Tissue and Cell Specificity of iHTNs.

Figure 3.

(A) A boxplot showing Spearman correlations in iHTNs (n = 12) and post-mortem adult HT tissue (aHT[UCIBB]) (n = 6) compared to GTEx hypothalamus (aHT [GTEx]) gene expression.

(B) Tissue Specific Expression Analysis (TSEA) of iHTNs (left) and aHT(UCIBB) (right) using GTEx, showing that lab-generated iHTNs are brain related in origin (green boundary) and express forebrain- and hypothalamus-specific genes similar to adult hypothalamus tissue.

(C) Cell-Type Specific Expression Analysis (CSEA) of iHTNs (left) and aHT (right) using BrainAtlas, showing that lab-generated iHTNs comprise predominantly hypothalamic neurons in culture.