FIG. 11.

Root-mean-square-deviation (RMSD) to the start configuration as a function of time (a) and frequency of measured distances between atoms in adjacent termini (b) for various hybrid double-layer Aβ₄₂ models. In these fibril models, the L-peptides have the wild type sequence while the DRI peptides are the K28E mutant. We show representative configurations for the fibril models 7-L/6-L:1D^* (c), 7-L/3-L:1-D^*:3-L (d), and 2:L-D^*-L-D^* (e).