TABLE 1.

Simulation results using the nonparametric model for scenarios 1 to 6 from Thall and Cook.³¹(p, q): DLT risk and immune response probability. Dose levels that are safe (p ≤ p_T) and have the highest immune response probability are in bold. %: rate of reporting a dose level. N: average number of patients treated. (D, R): average number of DLTs and immune responses. Note that the total rate of reporting any dose level is less than 100% when the chance that dose level 1 is considered too toxic is larger than 0 (eg, in scenarios 5 and 6)

Scenario	Dose Level
		1	2	3	4	5	Total
1	(p, q)	(0.01,0.05)	(0.02,0.2)	(0.03,0.35)	(0.04,0.6)	(0.05,0.8)
	%	2.1	6.2	3.7	4.3	83.7	100
	N	7.47	8.48	8.16	8.05	8.01	40.17
	(D,R)	(0.08,0.38)	(0.14,1.65)	(0.24,2.89)	(0.34,4.81)	(0.43,6.39)	(1.23,16.12)
2	(p, q)	(0.01,0.57)	(0.03,0.58)	(0.06,0.6)	(0.2,0.62)	(0.32,0.64)
	%	21.7	20.3	27.7	20	10.3	100
	N	7.5	8.3	7.16	5.98	2.93	31.88
	(D,R)	(0.08,4.3)	(0.28,4.84)	(0.46,4.34)	(1.23,3.66)	(0.99,1.92)	(3.04,19.06)
3	(p, q)	(0.02,0.2)	(0.03,0.4)	(0.04,0.6)	(0.06,0.68)	(0.2,0.74)
	%	4.1	5	12.9	24.9	53.1	100
	N	7.86	8.34	8.3	8.36	8.46	41.32
	(D,R)	(0.14,1.55)	(0.24,3.29)	(0.32,5.03)	(0.49,5.67)	(1.71,6.27)	(2.91,21.81)
4	(p, q)	(0.01,0.52)	(0.01,0.62)	(0.02,0.71)	(0.03,0.79)	(0.03,0.86)
	%	12.4	10.9	7.9	6.4	62.4	100
	N	7.46	7.58	6.96	6.1	5.59	33.68
	(D,R)	(0.07,3.85)	(0.11,4.68)	(0.16,4.9)	(0.14,4.87)	(0.16,4.8)	(0.63,23.09)
5	(p, q)	(0.18,0.05)	(0.22,0.2)	(0.26,0.35)	(0.3,0.47)	(0.33,0.58)
	%	15.6	24.1	24	15.6	9.9	89.2
	N	11.65	10.57	8.35	5.26	2.58	38.4
	(D,R)	(2.09,0.6)	(2.22,2.03)	(2.2,3.04)	(1.6,2.5)	(0.89,1.53)	(9,9.7)
6	(p, q)	(0.08,0.15)	(0.18,0.38)	(0.25,0.52)	(0.3,0.59)	(0.35,0.62)
	%	14.9	26.7	29.1	19.7	8.2	98.6
	N	10	11.32	9.5	6	2.62	39.44
	(D,R)	(0.8,1.49)	(2.03,4.25)	(2.39,4.91)	(1.82,3.5)	(0.96,1.71)	(7.99,15.85)