TABLE 2.
Selected percentage followed by the average number of patients treated in parenthesis. Dose levels with bold (p, q) are the optimal dose level(s) in each scenario. The numbers in the parenthesis following the design are batch sizes
| Scenario | Dose Level | ||||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | Total | ||
| 7 | (p, q) | (0.01,0.05) | (0.02,0.25) | (0.03,0.25) | (0.04,0.25) | (0.05,0.25) | |
| Nonparametric(7) | 1.8(7.4) | 20(8.4) | 20(8.4) | 15.4(6.6) | 42.8(5.3) | 100(36.1) | |
| EffTox(7) | 5(9.1) | 52(18.2) | 32(11.1) | 4(1.2) | 1(0.2) | 94(39.8) | |
| EffTox(3) | 4(5.6) | 40(15.2) | 26(10.9) | 10(3.4) | 5(1.1) | 85(36.2) | |
| UAROET(6) | 0.5(7.5) | 16.2(12) | 29.7(11.1) | 34.4(7) | 15.5(3.5) | 96.3(41.1) | |
| UAROET(3) | 0.2(4.5) | 11(8.8) | 25(10) | 28.8(9.2) | 30.5(8.1) | 95.5(40.7) | |
| 8 | (p, q) | (0.01,0.05) | (0.02,0.25) | (0.03,0.4) | (0.04,0.4) | (0.05,0.4) | |
| Nonparametric(7) | 1.5(7.5) | 7.5(8.2) | 21.5(8.1) | 17.6(7.7) | 51.9(6.2) | 100(37.7) | |
| EffTox(7) | 4(8.8) | 31(14.8) | 52(15) | 7(1.4) | 1(0.2) | 95(40.2) | |
| EffTox(3) | 4(5.5) | 27(11.9) | 48(16.9) | 11(3.2) | 2(0.8) | 92(38.3) | |
| UAROET(6) | 0.3(7.2) | 12.5(11.1) | 33.8(12.5) | 34.7(7.2) | 16.5(3.3) | 97.8(41.3) | |
| UAROET(3) | 0.1(4.4) | 4.9(8.4) | 28.2(11.1) | 34.1(9.5) | 30.3(7.8) | 97.6(41.2) | |
| 9 | (p, q) | (0.01,0.05) | (0.02,0.25) | (0.03,0.4) | (0.04,0.6) | (0.05,0.6) | |
| Nonparametric(7) | 1.4(7.5) | 7.3(8.1) | 7.1(8.2) | 19.4(7.8) | 64.8(7.2) | 100(38.8) | |
| EffTox(7) | 3(8.6) | 32(14.8) | 47(14.3) | 9(1.7) | 3(0.2) | 94(39.6) | |
| EffTox(3) | 5(5.7) | 22(10.9) | 39(14.7) | 18(4.8) | 4(0.9) | 88(37) | |
| UAROET(6) | 0.6(7.4) | 9.1(11) | 28.2(11.9) | 40.3(7.8) | 19.3(3.1) | 97.5(41.3) | |
| UAROET(3) | 0(4.3) | 3.7(7.7) | 16.4(9.9) | 40.4(10.9) | 37(8.4) | 97.5(41.2) | |
| 10 | (p, q) | (0.01,0.05) | (0.02,0.25) | (0.03,0.05) | (0.04,0.05) | (0.05,0.05) | |
| Nonparametric(7) | 1.2(7.6) | 65.7(8.3) | 10.3(9.2) | 5.2(3.8) | 17.6(2.6) | 100(31.5) | |
| EffTox(7) | 5(9.4) | 78(22.6) | 4(6.2) | 2(0.7) | 1(0.3) | 90(39.2) | |
| EffTox(3) | 5(5.7) | 54(19.7) | 6(4.2) | 5(1.8) | 3(1.2) | 73(32.6) | |
| UAROET(6) | 0.5(7.4) | 22.3(12.2) | 17.9(8.2) | 21.7(5.9) | 8.5(3.8) | 70.9(37.5) | |
| UAROET(3) | 0.6(4.4) | 16.3(10) | 18.7(8) | 17.9(7.1) | 10.3(6.1) | 63.8(35.7) | |
| 11 | (p, q) | (0.01,0.05) | (0.02,0.2) | (0.03,0.4) | (0.04,0.15) | (0.05,0.15) | |
| Nonparametric(7) | 2.3(7.5) | 4.7(8.4) | 61.2(8.2) | 10.7(7.3) | 21.1(3) | 100(34.5) | |
| EffTox(7) | 5(9.5) | 23(12.2) | 61(15.9) | 3(1.5) | 0(0) | 92(39.1) | |
| EffTox(3) | 4(5.7) | 19(9.5) | 58(19.1) | 5(2.1) | 3(0.7) | 89(37.1) | |
| UAROET(6) | 0.3(7.3) | 11.3(11) | 44.2(12.6) | 29.8(6.7) | 9.8(3.3) | 95.4(40.8) | |
| UAROET(3) | 0.3(4.6) | 6.5(7.8) | 44(12.7) | 26.9(8.6) | 16.5(6.8) | 94.2(40.5) | |
| 12 | (p, q) | (0.01,0.05) | (0.02,0.2) | (0.03,0.3) | (0.04,0.6) | (0.05,0.3) | |
| Nonparametric(7) | 1.7(7.5) | 8.3(8.4) | 2.2(8.4) | 62.6(7.9) | 25.2(6.9) | 100(39.1) | |
| EffTox(7) | 6(9.2) | 32(14) | 39(13.5) | 13(2.2) | 2(0.3) | 92(39.2) | |
| EffTox(3) | 4(5.7) | 25(11.1) | 28(11.3) | 29(8) | 2(0.8) | 88(36.9) | |
| UAROET(6) | 0.2(7.5) | 10(10.7) | 24.1(10.9) | 49.2(8.7) | 13.4(3.3) | 96.9(41.1) | |
| UAROET(3) | 0.1(4.4) | 6(8) | 13.8(10) | 49.6(11.3) | 27.2(7.3) | 96.7(41) | |
| 13 | (p, q) | (0.01,0.05) | (0.02,0.05) | (0.03,0.3) | (0.04,0.05) | (0.05,0.05) | |
| Nonparametric(7) | 15.1(7.4) | 0.8(9.5) | 64.2(7.3) | 6.2(7.3) | 13.7(2.4) | 100(34) | |
| EffTox(7) | 15(12.6) | 8(8.8) | 57(14.4) | 6(2.5) | 2(0.2) | 88(38.5) | |
| EffTox(3) | 6(6.7) | 6(4.9) | 51(16.6) | 5(2.7) | 3(1.1) | 71(32) | |
| UAROET(6) | 0.6(7.4) | 2.1(6.7) | 46.3(13.8) | 20.5(6.6) | 9(3.3) | 78.5(38) | |
| UAROET(3) | 0.2(4.4) | 1.9(5.5) | 42.4(13.1) | 15.5(7.3) | 11.7(5.6) | 71.7(35.9) | |
| 14 | (p, q) | (0.01,0.05) | (0.02,0.05) | (0.03,0.05) | (0.04,0.3) | (0.05,0.05) | |
| Nonparametric(7) | 13.3(7.5) | 14.8(9.5) | 0.6(8.9) | 55.1(6.7) | 16.2(6.2) | 100(38.8) | |
| EffTox(7) | 20(13.9) | 18(10.9) | 7(6.2) | 32(4.9) | 4(1.3) | 81(37.2) | |
| EffTox(3) | 8(6.8) | 8(6) | 8(4.5) | 40(11) | 4(2.1) | 68(30.4) | |
| UAROET(6) | 0.6(7.3) | 3.3(6.6) | 7.3(6.5) | 43.8(11.2) | 22.9(6.3) | 77.9(37.9) | |
| UAROET(3) | 0.5(4.3) | 0.8(5.1) | 6.2(6) | 36.1(11.2) | 29.1(9.6) | 72.7(36.2) | |
| 15 | (p, q) | (0.01,0.05) | (0.02,0.05) | (0.03,0.05) | (0.04,0.05) | (0.05,0.3) | |
| Nonparametric(7) | 15(7.5) | 13.2(9.5) | 11.9(8.6) | 0.9(7.7) | 59(5.4) | 100(38.6) | |
| EffTox(7) | 20(13.7) | 18(10.6) | 13(7.2) | 9(3.2) | 16(1.8) | 76(36.5) | |
| EffTox(3) | 10(7.3) | 8(5.7) | 9(5.1) | 8(3.2) | 28(7.1) | 63(28.4) | |
| UAROET(6) | 0.5(7.4) | 4.3(6.6) | 6.6(6.5) | 13.4(6.4) | 52.9(10.9) | 77.7(37.8) | |
| UAROET(3) | 0.1(4.4) | 1.8(5.3) | 4.8(5.8) | 9.2(6.5) | 57.9(14) | 73.8(36) | |