Figure 8.

MA consumption is reduced in MAHDR mice after prolonged periods of forced MA abstinence (Abst) to levels not significantly different from those of controls given access to MA for the first time. a: mean (± SEM) mg/kg/18h MA consumed across 4 days in MA-naïve controls (Group 1), and in MA-consuming mice before (day 28), and 1 week (Group 2) or 2 weeks (Group 3) after MA access is withdrawn. No MA consumption data are shown on Day 28 for Group 1, because they did not have access to MA until day 1 post-Abst. During the 4-day post-Abst drinking period, all animals had access to 1 water tube and 3, 80 mg/l MA tubes. b: mean (± SEM) total fluid consumed during the periods in A. **p<.01, ***p<.001, compared to the mean on day 28 for the main effect of day for the MA groups combined.