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. Author manuscript; available in PMC: 2020 Mar 15.
Published in final edited form as: AIDS. 2019 Mar 15;33(4):655–664. doi: 10.1097/QAD.0000000000002101

Table 4:

Longitudinal analyses. Univariable (unadjusted) and multivariable1 (adjusted) linear regression of longitudinal changes in FEV1 (mL/yr), FVC (mL/yr), and FEV1/FVC (x1000/yr) on log2-transformed baseline biomarkers.

Univariable
 Multivariable1
Lab value (log 2) β3 95% C.I. P-value β3 95% C.I. P-value
FEV1 Slope
D-dimer (mcg/ml) −0.4 −5.7, 4.9 0.88 −0.5 −5.8, 4.8 0.86
hsCRP (mcg/ml) 2.6 −0.1, 5.3 0.06 2.5 −0.2, 5.2 0.07
IL-6 (pg/ml) 0.9 −4.5, 6.4 0.73 0.9 −4.6, 6.3 0.75
IL-27 (pg/ml) −1.0 −3.8, 1.9 0.52 −0.9 −3.8, 2.0 0.54
Serum amyloid A (mg/L) 2.3 −0.8, 5.5 0.15 2.3 −0.8, 5.5 0.14
sICAM-1 (mcg/mL) 1.4 −6.0, 8.7 0.72 1.3 −6.1, 8.6 0.73
sVCAM-1 (mcg/mL) −4.2 −11.6, 3.1 0.26 −4.2 −11.5, 3.2 0.27
IL-6/D-dimer score2 2.0 −11.3, 15.3 0.77 1.7 −11.7, 15.0 0.81
Albumin (g/dL) −10.7 −47.5, 26.2 0.57 −9.1 −45.9, 27.8 0.63
Total bilirubin (mg/dL) −2.2 −8.7, 4.3 0.50 −2.1 −8.6, 4.4 0.53
FVC Slope
D-dimer (mcg/ml) −1.4 −7.5, 4.7 0.66 −1.6 −7.7, 4.6 0.62
hsCRP (mcg/ml) 1.4 −1.7, 4.6 0.38 1.4 −1.8, 4.5 0.40
IL-6 (pg/ml) −0.6 −6.9, 5.7 0.86 −0.7 −7.0, 5.6 0.83
IL-27 (pg/ml) −0.8 −4.1, 2.5 0.64 −0.7 −4.0, 2.6 0.69
Serum amyloid A (mg/L) 1.8 −1.9, 5.4 0.34 1.8 −1.9, 5.4 0.34
sICAM-1 (mcg/mL) 4.3 −4.1, 12.8 0.31 4.4 −4.1, 12.8 0.31
sVCAM-1 (mcg/mL) −1.6 −10.1, 6.9 0.71 −1.3 −9.8, 7.3 0.77
IL-6/D-dimer score2 −2.1 −17.5, 13.4 0.79 −2.7 −18.2, 12.8 0.73
Albumin (g/dL) −6.7 −49.6, 36.1 0.76 −2.9 −45.9, 40.1 0.89
Total bilirubin (mg/dL) 1.6 −5.9, 9.2 0.67 1.8 −5.7, 9.4 0.63
FEV1/FVC Slope
D-dimer (mcg/ml) −0.1 −0.8, 0.7 0.84 −0.1 −0.8, 0.7 0.89
hsCRP (mcg/ml) 0.3 −0.1, 0.7 0.11 0.3 −0.1, 0.7 0.10
IL-6 (pg/ml) 0.3 −0.4, 1.1 0.38 0.4 −0.4, 1.1 0.36
IL-27 (pg/ml) 0.0 −0.4, 0.4 0.84 0.0 −0.4, 0.4 0.87
Serum amyloid A (mg/L) 0.2 −0.2, 0.7 0.29 0.2 −0.2, 0.7 0.29
sICAM-1 (mcg/mL) −0.4 −1.4, 0.6 0.40 −0.4 −1.4, 0.6 0.40
sVCAM-1 (mcg/mL) −0.7 −1.7, 0.3 0.20 −0.7 −1.7, 0.3 0.18
IL-6/D-dimer score2 0.6 −1.2, 2.5 0.50 0.7 −1.1, 2.5 0.47
Albumin (g/dL) 0.2 −4.8, 5.2 0.94 0.0 −5.1, 5.0 0.99
Total bilirubin (mg/dL) −0.7 −1.6, 0.2 0.12 −0.7 −1.6, 0.2 0.12
1

adjusted for age, sex, race, region, smoking status, treatment group (immediate vs. deferred antiretroviral treatment initiation), CD4+ T-cell count, and HIV-RNA.

2

[0.33 × log2 IL-6 + 0.16 × log2 D-dimer] [17]

3

β represent the difference in lung function slope (FEV1, FVC, or FEV1/FVC) associated with a doubling of the corresponding biomarker