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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Brain Behav Immun. 2018 Dec 11;77:55–65. doi: 10.1016/j.bbi.2018.12.004

Figure 3: Poly(I:C) increases alcohol intake across multiple doses.

Figure 3:

(A) C57BL/6J male mice were injected with saline, poly(I:C) (2mg/kg), or poly(I:C) (10mg/kg) every four days during a two-bottle choice every-other-day drinking procedure (EOD, 15% or 20%). (B) Ethanol (EtOH) intake (g/kg/24 h); (C) preference for EtOH; (D) total fluid intake. Dashed line represents a “no injection” period during which animals continued EOD without injections. Data represented as mean ± s.e.m. (****p<0.0001, ***p<0.0002, **p<0.0021, *p<0.05 for Bonferroni post-hoc tests, n=10 per group).