Figure 1.

Operant sensation seeking in the BXD recombinant inbred mouse panel. A, B, Mice rapidly learned to press the active lever to receive a combination auditory‐tactile‐visual reward. Males learned to discriminate between the active and inactive levers more rapidly than females. C, Males received significantly more auditory‐tactile‐visual rewards than females during many of the testing sessions. D, Preference for the active lever increased significantly across sessions until it stabilized on sessions 11 to 19 in both males and females. E‐H, Response patterns on the final session indicate modest within‐session variation across blocks but do not indicate within‐session habituation of the reinforcing effectiveness of the auditory‐tactile‐visual stimuli. *P < 0.05; #P < 0.10