Figure 2.

Oss1 behavioral QTL associated with preference for an auditory‐tactile‐visual stimulus in an operant sensation seeking assay. A, Genome‐wide significant behavioral QTL on chromosome 4 (Oss1) associated with active lever preference on the final testing session of an operant sensation seeking assay. B, The 2‐LOD confidence interval for Oss1 was 506 kilobases and contained 16 protein coding genes. C, Oss1 accounted for 18% of the variance on active lever preference during the final session. D, E, Across sessions, mice with the B6 allele at Oss1 received significantly more rewards and exhibited significantly greater active lever preference relative to mice with the D2 allele. *P < 0.05; #P < 0.10