Figure 5.

Expression of Mef2c is associated with number of rewards in an operant sensation seeking assay. Mef2c is a positional candidate for Oss2. A, Genome‐wide significant cis‐eQTL associated with expression of Mef2c, which encodes myocyte enhancer factor 2C, was identified in the hippocampus. B, Expression of Mef2c mRNA in the hippocampus was positively genetically correlated with number of rewards on an operant sensation seeking assay. Data points represent BXD strain means. Black and gray colors signify the B6 and D2 alleles, respectively, at the peak of the Oss2 QTL. *P < 0.05