Table 1.

Parameter definitions and values used for numerical simulations (unless specified otherwise)

Parameter	Definition	Value
$\lambda$	Monomer source rate	1500
$\gamma$	Monomer degradation rate	5

		Strain 1	Strain 2
$\rho$	Conversion rate of normal monomers to subunits	5	1
$\omega$	Reconversion rate of subunits	1	1
K	Half-maximum concentration for the conversion kinetics	500	100
$\delta$	Degradation of subunits	2	2
$\tau$	Polymerization rate of subunits	0.1	0.2
$\beta$	Fragmentation rate of polymers	0.0003	0.1
$\mu$	Degradation rate of polymers	0.04	0.04
$x_0$	Nucleus size	6	6

The values are chosen arbitrarily, with magnitudes consistent with values from Masel et al. (1999), where time is expressed in days. The aggregate-associated quantities are in fibril number per volume unit