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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Matrix Biol. 2018 Sep 4;77:101–116. doi: 10.1016/j.matbio.2018.08.010

Figure 9. Growth factors induce Akt activation in CD cells adherent on LM by TRAF6-mediated K63-linked polyubiquitination and PI3K-dependent phosphorylation.

Figure 9.

Growth factors (GF: FGF10, GDNF) induce TRAF6-mediated K63-linked polyubiquination of Akt which facilitates Akt translocation to the cellular membrane (blue arrows). They also induce PI3K activation that changes phospholipid membrane composition resulting in Akt anchoring to the membrane where it is phosphorylated and fully activated (red arrows).