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. 2019 Feb 26;10:128. doi: 10.3389/fphar.2019.00128

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Copyright © 2019 Deng, Guo, Wei, Gao, Zhou and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of MCT-induced increase in right ventricular systolic pressure, hypertrophy, enlargement, and dysfunction by PNU-282987. (A) The representative right ventricular hemodynamic waves are presented in the sham, MCT, prevention, and treatment groups. (B) Right ventricular systolic pressure (RVSP) was determined. (C,D) RV hypertrophy was determined by RV weight normalized to body weight (BW) and the ratio of RV/[Left ventricle (LV) + septum (S)] among the four groups, respectively. (E) RV end diastolic dimension (RVEDD) and tricuspid annular plane systolic excursion (TAPSE) measured by echocardiography. (F,G) Comparison of the RVEDD and TAPSE by echocardiography in different groups. The data are summarized as means ± SD. ^∗P < 0.05 versus the sham group and ^#P < 0.05 versus the MCT group. Results shown are from one experiment (sham group, n = 15; MCT group, n = 8; MCT+protective group, n = 13; MCT+treatment group, n = 11).