Table 1.
Effect of pregabalin (30 mg kg-1, s.c) on IL-6, KC and TNFα concentration in bladder and plasmatic level in cyclophosphamide (CYP)-induced cystitis mice model.
| Cytokines | Saline/Saline (n = 8) | Saline/PGB (n = 8) | Cyp/Saline (n = 8) | CPY/PGB (n = 8) | |
|---|---|---|---|---|---|
| Bladder pg/ml/mg of bladder | IL-6 | 181,3 ± 11,5 | 190,4 ± 23,1 | 300,5 ± 40,2** | 166,2 ± 181,1 |
| KC | 772,6 ± 98,1 | 743,9 ± 91,8 | 1454,1 ± 215,2** | 210,6 ± 37,4* | |
| TNFα | 135,6 ± 7,5 | 146,4 ± 16,5 | 244,9 ± 30,3*** | 117,5 ± 13,6 | |
| Plasmatic pg/ml | IL-6 | 1473,8 ± 10,7 | 1627,6 ± 67,4 | 2942,9 ± 78,4*** | 1461,5 ± 58,9 |
| KC | 453,1 ± 65,7 | 289,1 ± 31,6 | 838,9 ± 105,4** | 491,7 ± 76,9 | |
| TNFα | 999,5 ± 334,8 | 728,7 ± 57,6 | 2098,9 ± 331,6*** | 927,6 ± 101,8 | |
The values are expressed as a mean I’S.E.M. and compared by a 1-way ANOVA (Treatment) followed by Tukey post hoc test for multiple comparisons. N = 8/group. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 vs. control group.