Table 3.
Comparison of the most common cardiovascular system abnormalities between children and adults with MFS
| All patients (n = 101) | Children (n = 44) | Adults (n = 57) | p (children vs. adults) | |
|---|---|---|---|---|
| Aortic root dilatation (%) | 81.19 | 75 | 85.96 | 0.202 |
| Aortic arch dilatation (%) | 8.91 | 2.27 | 14.04 | 0.040 |
| Descending thoracic and abdominal aorta dilatation (%) | 10.89 | 2.27 | 17.54 | 0.015 |
| Aortic dissection (%) | 7.92 | 4.55 | 10.53 | 0.270 |
| Type A aortic dissection (%) | 4.95 | 4.55 | 5.26 | 0.869 |
| Type B aortic dissection (%) | 2.97 | 0 | 5.26 | 0.122 |
| Pulmonary trunk dilatation (%) | 27.72 | 15.91 | 36.84 | 0.025 |
| Bicuspid aortic valve (%) | 3.96 | 6.82 | 1.75 | 0.196 |
| Mitral valve regurgitation (%) | 63.37 | 45.45 | 77.19 | 0.002 |
| Severe mitral valve regurgitation (%) | 9.90 | 4.55 | 14.04 | 0.113 |
| Mitral valve prolapse (%) | 54.46 | 56.82 | 52.63 | 0.692 |
| Frequent ventricular extrasystoles (%) | 8.91 | 4.55 | 12.28 | 0.176 |
| Frequent supraventricular extrasystoles (%) | 4.95 | 4.55 | 5.26 | 0.869 |
| Patients without prior surgery on ascending aorta (n = 84) | Children (n = 43) | Adults (n = 41) | p (children vs. adults) | |
|---|---|---|---|---|
| Aortic root diametera (z-score) | + 3.75 ± 1.63 | + 3.09 ± 0.93 | + 4.46 ± 1.91 | 0.001 |
| Aortic annulus dilatation (%) | 8.33 | 9.30 | 7.32 | 0.742 |
| Aortic annulus diametera (z-score) | + 2.74 ± 1.12 | + 2.66 ± 0.22 | + 2.67 ± 1.68 | 0.969 |
| STJ dilatation (%) | 33.33 | 25.58 | 41.46 | 0.123 |
| STJ diametera (z-score) | + 3.45 ± 2.01 | + 3.02 ± 1.98 | + 3.74 ± 1.75 | 0.056 |
| Distal ascending aorta dilatation (%) | 27.38 | 20.93 | 34.15 | 0.175 |
| Distal ascending aorta diametera (z-score) | + 3.19 ± 2.06 | + 3.16 ± 1.43 | + 3.22 ± 1.65 | 0.848 |
| Aortic valve regurgitation (%) | 30.95 | 25.58 | 36.59 | 0.490 |
Statistically significant differences are marked in bold
aAmong patients with dilation of this part of aorta