Table 1.

Demographic and clinicopathologic characteristics of non-metastatic ampullary carcinoma patients after surgery

Demographic or characteristic	Training dataset		Validation dataset		p value
	No. of patients	%	No. of patients	%
Sex					0.947
Male	725	56.8	425	57.0
Female	551	43.2	321	43.0
Age, years [median (IQR)]	66 (57–74)		64 (56–72)		0.021
Race					< 0.001
White	1017	79.7	534	71.6
Black	65	5.1	86	11.5
Others	194	15.2	126	16.9
Marital status					0.177
Yes	825	64.7	460	61.7
No	451	35.3	286	38.3
Grade					0.407
Well-differentiated	134	10.5	86	11.5
Moderately differentiated	710	55.6	386	51.7
Poorly differentiated	423	33.2	268	35.9
Undifferentiated	9	0.7	6	0.8
Histology					0.229
Adenocarcinoma	991	77.7	583	78.2
Others	285	22.3	143	21.8
Regional nodes examined [median (IQR)]	13 (8–19)		14 (9–12)		0.017
Regional nodes positive [median (IQR)]	1 (0–2)		1 (0–3)		0.003
LNR [median (IQR)]	0.05 (0.00–0.20)		0.07 (0.00–0.22)		0.010
Tumor size, mm [median (IQR)]	21 (15–30)		22 (15–32)		0.336
Extension range					0.842
Localized	156	12.3	92	12.3
Duodenal wall	364	28.5	203	27.2
P/C/E	490	38.4	284	38.1
Adjacent organs or tissues	266	20.8	167	21.4
AJCC stage					0.468
IA	123	9.6	67	9.0
IB	219	17.2	114	15.3
IIA	169	13.2	88	11.8
IIB	417	32.7	268	35.9
III	348	27.3	209	28.0

P/C/E pancreas, common bile duct, extrahepatic bile duct, LNR lymph node ratio, AJCC American Joint Committee on Cancer, IQR interquartile range