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. 2019 Feb 26;10:212. doi: 10.3389/fmicb.2019.00212

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Copyright © 2019 Allemann, Kraemer, Korten, Ramsey, Casaulta, Wüthrich, Ramette, Endimiani, Latzin and Hilty.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phylogenetic tree of predicted β-lactamases identified. Predicted protein sequences were obtained using ORFfinder (NCBI) (≥50 amino acids in length) using the genes received from functional metagenomics sequencing. β-lactamases (n = 64) were assigned to an Ambler class according the best hit from blast against NCBI. Sequences with less than 85% identity over 90% of sequence to known β-lactamase were classified as non-described proteins. All sequences were aligned with MUSCLE (software MEGA, 5.2.1) and an approximately-maximum-likelihood phylogenetic tree was built using FastTree (http://www.microbesonline.org/fasttree/, July 2017).