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. 2019 Mar 4;9:3392. doi: 10.1038/s41598-019-39533-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of bicalutamide and TGF-β on the collagen synthesis and associated fibrogenic proteins in RMC cells. (a) Transwell assay staining of the control, TGB-β-treated, and bicalutamide-treated RMC cells. (b) Quantification of the cell numbers on the transwell assay. (c) Quantification of sirius red for the collagen synthesis (numeral data was shown as Supplementary Table 1); and (d) Western blot on the expression of fibrogenic proteins PDGF-β, fibronectin, collagen IV, and SMA. Experiments were performed in triplicate and statistically treated (n = 3). The dose of bicalutamide used was 7.5, 15, 30 and 60 μM, respectively. T means Testosterone 100 nM.