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. 2019 Mar 4;10(3):223. doi: 10.1038/s41419-019-1443-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a In two groups of mice, we administered 15 nmol negative control and miR-184-3p agomir respectively, and detected the expression of miR-184 in the peripheral blood of these mice 24 h later. Unpaired student’s t-test (two-tailed) was used for comparison between two groups. ****P < 0.0001. Data represent mean ± SEM. b At the 11th day of pregnancy, we detected miR-184 expression in uteruses from pregnant mice. Unpaired student’s t-test (two-tailed) was used for comparison between two groups. ****P < 0.0001. Data represent mean ± SEM. c In two groups of mice, we administered negative control or miR-184-3p agomir once every 3 days respectively, and executed pregnant mice at the 11th day of pregnancy. Although administration with 5 nmol miR-184-3p agomir could increase the embryo resorption rate, there was no obvious difference between these two groups. However, administration with 15 nmol miR-184-3p agomir could significantly increase the embryo resorption rate. Arrows indicate the embryo resorption. Two-way ANOVA was used for comparison between the two groups. *P < 0.05. Data represent mean ± SEM. d TUNEL assay was used to compare the apoptosis of placental tissues between the two groups. Scale bar: 100 μm. Unpaired student’s t-test (two-tailed) was used for comparison between two groups. **P < 0.01. Data represent mean ± SEM. e Relative expression of miR-184 in villi tissues from normal pregnant women and abortion patients was detected by RT-PCR. (n = 13) And western blot was used to evaluate the expression of WIG1 in villi tissues from normal pregnant women and abortion patients. (n = 6) Unpaired student’s t-test (two-tailed) was used for comparison between two groups. **P < 0.01. Data represent mean ± SEM. f Expression of WIG1 was also tested in placental tissues from BALB/c mice receiving either negative control or miR-184-3p agomir. (n = 6) (Negative control: mice injected with negative control; miR-184-3p agomir: mice injected with miR-184-3p agomir.)