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. 2019 Mar 4;10(3):217. doi: 10.1038/s41419-019-1467-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The mRNA expression of NPTX2 in CRC and adjacent noncancerous tissues, as analyzed from TCGA dataset (Student’s t test). b The mRNA expression of NPTX2 in CRC and adjacent noncancerous tissues, as analyzed from GEO dataset (Student’s t test). c Overall survival analysis based on the mRNA expression of NPTX2 from TCGA dataset (Kaplan–Meier method and log-rank test). d, e The protein expression of NPTX2 in normal, CRC, and liver metastasis tissues in tissue microarray (392 cases of normal tissues, 392 matched cases of CRC tissues, and 30 cases of liver metastasis) (Spearman’s rank correlation). f, g NPTX2 protein expression at different pathological stages in CRC tissues from tissue microarray (34 cases of stage I, 150 cases of stage II, 127 cases of stage III, and 81 cases of stage IV CRC) (Spearman’s rank correlation). h Overall survival analysis of the protein expression of NPTX2 based on the prognostic information of patients with CRC from tissue microarray data (Kaplan–Meier method and log-rank test). Measurement data were presented as the mean ± SD. *P < 0.05; *** P < 0.0001