Table 1.
Genome-wide association study (GWAS) summary-data-based Mendelian randomization (SMR)
| Probe | Gene name | Gene ID | Single- nucleotide polymorphism (SNP) ID | eQTL P-value | GWAS P-value | SMR P-value |
|---|---|---|---|---|---|---|
| 9364_at | RAB28, member RAS oncogene family | RAB28 | rs17362130 | 1.14E-03 | 3.68E-05 | 4.84E-03 |
| 8737_at | Receptor (TNFRSF)-interacting serine-threonine kinase 1 | RIP1 | rs6918808 | 1.23E-03 | 4.01E-05 | 5.04E-03 |
| 7289_at | Tubby like protein 3 | TULP3 | rs2238087 | 1.14E-03 | 2.58E-04 | 1.27E-02 |
| 808_at | Calmodulin 3 (phosphorylase kinase, delta) | CALM3 | rs4802363 | 1.76E-03 | 1.99E-03 | 1.28E-02 |
| 11133_at | Kaptin (actin binding protein) | KPTN | rs4802363 | 1.98E-03 | 2.91E-03 | 1.30E-02 |
| 8605_at | Phospholipase A2, group IVC (cytosolic, calcium-independent) | PLA2G4C | rs4802363 | 1.72E-03 | 4.62E-03 | 1.33E-02 |
| 57820_at | Cyclin B1 interacting protein 1, E3 ubiquitin protein ligase | CCNB1lP1 | rs10130942 | 1.41E-03 | 3.98E-03 | 1.86E-02 |
| 10082_at | Glypican 6 | GPC6 | rs17181808 | 1.06E-03 | 6.41E-04 | 1.86E-02 |
| 1690_at | coagulation factor C homolog, cochlin (Limulus polyphemus) | COCH | rs12436395 | 3.52E-04 | 1.88E-02 | 2.03E-02 |
| 120227_at | Cytochrome P450, family 2, subfamily R, polypeptide 1 | CYP2R1 | rs2167453 | 4.40E-05 | 2.56E-02 | 2.10E-02 |
| 579_at | NK3 homeobox 2 | NKX3–2 | rs17362130 | 2.11E-03 | 1.18E-03 | 2.72E-02 |
| 80759_at | KH homology domain containing 1 | KHDC1 | rs4706511 | 1.01E-03 | 5.49E-03 | 3.47E-02 |
| 10553_at | HIV-1 Tat interactive protein 2, 30 kDa | HTATIP2 | rs10766743 | 1.85E-03 | 2.11E-03 | 3.60E-02 |
| 79624_at | Chromosome 6 open reading frame 211 | C6orf211 | rs13201167 | 4.40E-04 | 2.47E-03 | 3.65E-02 |
| 160897_at | G protein-coupled receptor 180 | GPR180 | rs17181808 | 4.40E-04 | 5.04E-03 | 3.66E-02 |
| 5272_at | Serpin peptidase inhibitor, clade B (ovalbumin), member 9 | SERPINB9 | rs6918808 | 1.01E-03 | 3.04E-03 | 3.80E-02 |
| 23483_at | TDP-glucose 4,6-dehydratase | TGDS | rs17181808 | 4.84E-04 | 6.32E-03 | 3.82E-02 |
| 440145_at | Mitotic spindle organizing protein 1 | MZT1 | rs17089906 | 2.64E-04 | 9.85E-03 | 4.20E-02 |
| 9590_at | A kinase (PRKA) anchor protein 12 | AKAP12 | rs13201167 | 2.16E-03 | 3.63E-03 | 4.27E-02 |
| 688_at | Kruppel-like factor 5 (intestinal) | KLF5 | rs17089906 | 1.76E-04 | 2.01E-02 | 4.54E-02 |
| 7767_at | Zinc finger protein 224 | ZNF224 | rs2734459 | 7.04E-04 | 3.59E-03 | 4.66E-02 |
| 348_at | Apolipoprotein E | APOE | rs2734459 | 1.23E-03 | 5.19E-03 | 5.55E-02 |
| 81029_at | Wingless-type MMTV integration site family, member 5B | WNT5B | rs2238087 | 1.98E-03 | 6.45E-03 | 5.65E-02 |
| 404550_at | Chromosome 16 open reading frame 74 | C16orf74 | rs7204305 | 1.98E-03 | 6.74E-03 | 5.67E-02 |
| 11129_at | CLK4-associating serine/arginine rich protein | CLASRP | rs2734459 | 2.64E-04 | 1.32E-02 | 8.43E-02 |
| 131583_at | Family with sequence similarity 43, member A | FAM43A | rs923934 | 4.40E-05 | 1.90E-02 | 8.89E-02 |