Table 2.
Pathway enrichment analysis with PASCAL detects 12 putative pathways related to multiple myeloma. Combined P-values are obtained with Brown’s method. PX denotes P-value obtained from interaction test of set X
| Database | Pathway | ||||
|---|---|---|---|---|---|
| REACTOME | Circadian repression of expression by REV-ERBA | 3.50E-04 | 1.45E-01 | 4.16E-03 | 5.52E-04 |
| APOBEC3G mediated resistance to HIV infection | 5.79E-02 | 1.74E-03 | 2.09E-03 | 1.02E-03 | |
| RORA activates circadian expression | 1.24E-03 | 1.83E-01 | 1.20E-02 | 2.13E-03 | |
| Deposition of new CENP-A containing nucleosomes as the centromere | 7.00E-02 | 7.49E-03 | 3.82E-03 | 4.48E-03 | |
| SMAD2 SMAD3 SMAD4 heterotrimer regulates transcription | 8.83E-02 | 7.81E-03 | 1.88E-02 | 5.70E-03 | |
| TGFβ receptor signaling activates SMADs | 1.73E-02 | 6.39E-02 | 4.38E-03 | 8.60E-03 | |
| GABAA receptor activation | 2.36E-02 | 6.27E-02 | 1.62E-02 | 1.11E-02 | |
| Iron uptake and transport | 4.84E-02 | 4.20E-02 | 8.91E-03 | 1.46E-02 | |
| Transcriptional activity of SMAD2 SMAD3 SMAD4 heterotrimer | 9.53E-02 | 2.18E-02 | 4.15E-02 | 1.49E-02 | |
| Purine salvage | 8.82E-02 | 2.51E-02 | 3.71E-02 | 1.57E-02 | |
| Apoptosis induced DNA fragmentation | 1.76E-02 | 1.29E-01 | 2.32E-02 | 1.60E-02 | |
| BIOCARTA | ALK pathway | 9.49E-03 | 3.28E-02 | 3.12E-02 | 2.82E-03 |