Table 2.
Epidemiologic characteristics of clusters.
| Cohort | Cluster (n) | Sex (M/F) | Age (mean ± SD) | BMI (mean ± SD) | HTN (−/+) | FHDM (−/+) | DM (−/+ prevalence) |
|---|---|---|---|---|---|---|---|
| Discovery (AA, n = 10023) | CL1 (1985) | M | 45.72 ± 4.13 | 24.22 ± 2.81 | (−) | (−) | 1808/177 (0.09)ǂ |
| CL2 (3241) | F | 51.04 ± 8.74 | 24.35 ± 3.15 | (−) | (−) | 2937/304 (0.09) | |
| CL3 (862) | 374/488 | 47.89 ± 6.90 | 24.61 ± 2.95 | (−) | (+) | 690/172 (0.20) | |
| CL4 (1013) | M | 61.87 ± 4.23 | 23.11 ± 2.90 | (−) | (−) | 807/206 (0.20) | |
| CL5 (2645) | 1258/1387 | 56.41 ± 8.57 | 25.50 ± 3.21 | (+) | (−) | 2050/595 (0.22) | |
| CL6 (277) | 122/155 | 53.27 ± 8.45 | 26.20 ± 3.06 | (+) | (+) | 156/121 (0.44) | |
| Validation (CAVAS HEXA KNHANES, n = 215083) | CL1 (24768) | M | 46.84 ± 4.66 | 24.09 ± 2.88 | (−) | (−) | 23761/1007 (0.04) |
| CL2 (83436) | F | 51.90 ± 7.91 | 23.40 ± 2.85 | (−) | (−) | 80783/2653 (0.03) | |
| CL3 (27465) | 8099/19366 | 50.55 ± 7.72 | 23.73 ± 2.88 | (−) | (+) | 24390/3075 (0.11) | |
| CL4 (19271) | M | 61.70 ± 4.41 | 23.60 ± 2.62 | (−) | (−) | 17374/1897 (0.10) | |
| CL5 (50155) | 21231/28924 | 57.33 ± 7.80 | 25.09 ± 3.06 | 31/50124† | 50136/19† | 41636/8519 (0.17) | |
| CL6 (9988) | 3784/6204 | 55.50 ± 7.95 | 25.29 ± 3.03 | (+) | (+) | 6823/3165 (0.32) |
M: male, F: female, BMI: body mass index, HTN: hypertension, FHDM: family history of diabetes, DM: diabetes, CL: cluster. AA: Ansan/Ansung, HEXA: Health Examinees study, CAVAS: Cardiovascular Association Study, KNHANES: Korea National Health and Nutrition Examination Survey.
†Although hypertension status and FHDM in cluster 5 show single results in discovery cohort, both statuses appear in cluster 5 of the validation cohort.
ǂThe prevalence is expressed to 2 digits after the decimal point.