Table 1.

Experimental domain and the relative significance (with their sign) of the main effects associated to each factor as well as the quadratic interaction of desorption flow.

Experimental factors	Levels			Effects of the experimental factors on the compound specific chromatographic areas
	(−1)	0	(+1)	TEP	TPP	TNBP	TCEP	TCIPP	TDCIPP	TBOEP	TPHP	EHDPP	TEHP
Desorption flow rate (A)	20	60	100	+	+	+	++	+	++	++	++	++	++
Desorption temperature (B)	260	290	320	+	+	−	+	−	++	++	++	++	++
TDS transfer line temperature (C)	260	290	320	++	+	+	+	+	++	+	++	++	++
Desorption time (D)	5	10	15	+	+	+	+	+	+	++	+	+	++
Cryofocusing temperature (E)	−100	−20	60	−−−	+	+++	+++	+++	+++	+++	+++	+++	+++
Cryodesorption temperature (F)	260	290	320	+++	++	++	++	++	++	++	++	++	+++
Cryodesorption time (G)	2	6	10	−	−	−	+	+	−	+	−	+	+
AA	20	60	100	−−−	−−−	−−−	−−−	−−−	−−−	−−	−−−	−−−	−−−

+++ or −−− indicate a statistically significant (p < 0.05) positive or negative effect. ++ or −−indicate a positive or negative effect that was close to statistical significance. + or − indicate a positive or negative effect that was far from reaching statistical significance.