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. 2019 Mar 4;9:3421. doi: 10.1038/s41598-019-39846-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SAA-enriched HDL induced MCP-1 mRNA expression is TLR2 and TLR4 dependent. (A) MCP-1 mRNA expression in rVSMC upon HDL (100 µg/ml) and OxPAPC (30 µg/ml) stimulation for 4 h. (B) Aortic tissue of TLR2_ko, TLR4_def and TLR2_ko/TLR4_def mice in comparison to control wild type littermates (wt) were stimulated ex vivo with HDL (100 µg/ml) isolated from septic patients (HDL_septic) for 24 h. MCP-1 protein secretion was determined in the supernatant and normalized to the aortic dry weight. Data are presented as means ± SEM. *p < 0.05 compared to control (ctrl.).