Table 4.
Variant/gene-drug pairs currently listed in PharmGKB database (October 9th, 2018).
| Variant | Gene | Type | Level of evidence | Chemicals |
|---|---|---|---|---|
| rs12044852 | CD58 | Efficacy | 3 | Interferon beta-1a, interferon beta-1b |
| rs4278350 | – | Efficacy | 3 | Interferon beta-1a, interferon beta-1b |
| rs760316 | FHIT | Efficacy | 3 | Interferon beta-1a, interferon beta-1b |
| rs1448673 | – | Efficacy | 3 | Interferon beta-1a, interferon beta-1b |
| rs10819043 | GAPVD1 | Efficacy | 3 | Interferon beta-1a, interferon beta-1b |
| rs3133084 | – | Efficacy | 3 | Interferon beta-1a, interferon beta-1b |
| rs10494227 | ZNF697 | Efficacy | 3 | Interferon beta-1a, interferon beta-1b |
| rs2291858 | GAPVD1 | Efficacy | 3 | Interferon beta-1a, interferon beta-1b |
| rs10760397 | GAPVD1 | Efficacy | 3 | Interferon beta-1a, interferon beta-1b |
| HLA-DRB1*04:01:01 | HLA-DRB1 | Efficacy | 3 | Interferon beta-1a |
| HLA-B*15:01:01:01 | HLA-B | Efficacy | 3 | Interferon beta-1a |