Table 1.
Characterization of cultured cells for 6 weeks.
| GM-CSF/SCF | G-CSF/SCF | M-CSF/SCF | ||
|---|---|---|---|---|
| Level of HLA-DR | low | low | high | Figure 1F |
| CD11b+CD33+ | high | dim | high | Figure 1D |
| Monocyte (CD14):Granulocytes(CD15) ratio | 9: 1 (M-MDSCs) | 2: 8 | 10:0 | Figure 1F |
| Level of Arginase 1 and IDO | +++ | + | ++ | Figure 3A |
| Suppressive activity | +++ | ++ | + | Figure 4A |
| Treg induction | +++ | ++ | ++ | Figure 4B |
Typical nomenclature of human myeloid derived suppressor cells (MDSCs): HLA-DRnegative or low, CD11b+CD33+, CD14+: Monocytic MDSCs (M-MDSCs). HLA-DRnegative or low, CD11b+CD33+, CD15+: Granulocytic MDSCs (G-MDSCs).