Table 1.
Activation of TNFRSF receptors by soluble TNFSF ligands and TNFRSF-specific antibodies
| Receptor Type |
Cellular response | Soluble ligand: EC50w/o crosslinking/ EC50with crosslinking |
Antibody: EC50w/o crosslinking/ EC50with crosslinking |
|---|---|---|---|
| 4-1BB | IL8 | »10028 | >10 |
| CD27 | IL8 | »10028 | >100 |
| CD40 | IL8 | 5–2528 | >100 |
| CD95 | Cell death | 100–»100037,38 | >100 |
| Fn14 | IL8 | >10032,37,39 | »100 |
| GITR | IL8 | ~528 | Not detectable |
| LTßR | IL8 | 134 | 1 |
| Ox40 | IL8 | ~10029 | >100 |
| TNFR1 | Cell death | 137 | 1 |
| TNFR2 | Proliferation | Differ in max. response37 | >100 |
| TRAILR1 | Cell death | 70–»100040,41 | >100 |
| TRAILR2 | Cell death | 70–»100040,41 | >100 |