Table 1.
ACVR1 R206H and H3.1K27M significantly decrease survival
| Virus combination | p value |
|---|---|
| ACVR1 R206H; H3.1K27M vs ACVR1 WT; H3.1K27M | 0.0048** |
| ACVR1 R206H; H3.1K27M vs ACVR1 R206H; H3.1 WT | <0.0001**** |
| ACVR1 R206H; H3.1K27M vs ACVR1 WT; H3.1 WT | 0.0038** |
| ACVR1 R206H; H3.1K27M vs ACVR1 WT | 0.0005*** |
| ACVR1 R206H; H3.1K27M vs H3.1K27M | 0.0002*** |
| ACVR1 R206H; H3.1K27M vs RCAS Y | 0.0002*** |
| ACVR1 R206H; H3.1K27M vs BMP4 | 0.0001*** |
| ACVR1 R206H; H3.3K27M vs ACVR1 R206H; H3.1 WT | 0.0002*** |
| ACVR1 R206H; H3.3K27M vs ACVR1 WT | 0.0344* |
| ACVR1 R206H; H3.3K27M vs H3.1K27M | 0.0163* |
| ACVR1 R206H; H3.3K27M vs RCAS Y | 0.0183* |
| ACVR1 R206H; H3.3K27M vs BMP4 | 0.0096** |
| ACVR1 WT; H3.1K27M vs ACVR1 R206H | 0.0391* |
| ACVR1 R206H; H3.1 WT vs ACVR1 WT; H3.1 WT | 0.0331* |
| ACVR1 R206H; H3.1 WT vs ACVR1 R206H | <0.0001**** |
| ACVR1 R206H vs RCAS Y | 0.0058** |
| ACVR1 R206H vs ACVR1 WT | 0.0098** |
| ACVR1 R206H vs BMP4 | 0.0037** |
| ACVR1 R206H vs H3.1K27M | 0.0056** |
*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, log-rank test