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. 2019 Feb 26;13:171. doi: 10.3389/fnins.2019.00171

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Copyright © 2019 Alonso, Pisa and Carrasco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Three- and two-dimensional principal component analysis of bacteria of CNS regions from ALS patients and AD patients. Comparison of three separate CNS regions between AD and ALS patients. (A) Left panel: three-dimensional (3D) principal component analysis (PCA) between MC regions of ten ALS patients (plots in red) and 10 AD patients (plots in blue). Right panel: 2D PCA. (B) Left panel: 3D PCA between MD regions of eleven ALS patients (plots in blue) and ten AD patients (plots in red). Right panel: 2D PCA. (C) Left panel: 3D PCA between SC regions of 11 ALS patients (plots in blue) and 10 AD patients (plots in red). Right panel: 2D PCA. The UniFrac method was used to calculate this parameter. MC, motor cortex; MD, medulla; SC, spinal cord.